Potential Influence of the Microbiome on Infertility and ART
Potential Influence of the Microbiome on Infertility and ART
Prophylactic antibiotics are commonly used as part of IVF-ET protocols to prevent infections after invasive pelvic procedures. Moore et al found no evidence of reduced virulent bacteria or H2O2-producing lactobacilli with the use of doxycycline in IVF-ET setting. Other studies conducted with prophylactic administration of ceftriaxone or intravenous metronidazole demonstrated reduction in virulent bacteria on the transfer catheter and improved pregnancy rate, but were lacking a control group and did not check for the presence of H2O2-producing lactobacilli. Thus, the role of prophylactic antibiotics and its effect on implantation in the setting of IVF-ET still remains to be determined.
The Role of Prophylactic Antibiotics
Prophylactic antibiotics are commonly used as part of IVF-ET protocols to prevent infections after invasive pelvic procedures. Moore et al found no evidence of reduced virulent bacteria or H2O2-producing lactobacilli with the use of doxycycline in IVF-ET setting. Other studies conducted with prophylactic administration of ceftriaxone or intravenous metronidazole demonstrated reduction in virulent bacteria on the transfer catheter and improved pregnancy rate, but were lacking a control group and did not check for the presence of H2O2-producing lactobacilli. Thus, the role of prophylactic antibiotics and its effect on implantation in the setting of IVF-ET still remains to be determined.