Scleredema Differential Diagnoses
Differential Diagnoses
- Amyloidosis
- Cellulitis
- Eosinophilia-Myalgia Syndrome
- Eosinophilic Fasciitis
- Morphea
- Nephrogenic Systemic Fibrosis
- Primary Systemic Amyloidosis
- Sclerema Neonatorum
- Scleromyxedema
- Subcutaneous Fat Necrosis of the Newborn
- Systemic Sclerosis
Workup
Lisa K Pappas-Taffer, MD Assistant Professor of Clinical Dermatology, University of Pennsylvania School of Medicine
Lisa K Pappas-Taffer, MD is a member of the following medical societies: American Academy of Dermatology, Association of Professors of Dermatology, Medical Dermatology Society, Rheumatologic Dermatology Society
Coauthor(s)
Victoria P Werth, MD Professor of Dermatology and Medicine, University of Pennsylvania School of Medicine; Chief, Division of Dermatology, Philadelphia Veterans Affairs Medical Center
Victoria P Werth, MD is a member of the following medical societies: American Academy of Dermatology, American College of Physicians, American College of Rheumatology, Phi Beta Kappa, Society for Investigative Dermatology, Medical Dermatology Society
Specialty Editor Board
Richard P Vinson, MD Assistant Clinical Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine; Consulting Staff, Mountain View Dermatology, PA
Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Texas Medical Association, Association of Military Dermatologists, Texas Dermatological Society
Lester F Libow, MD Dermatopathologist, South Texas Dermatopathology Laboratory
Lester F Libow, MD is a member of the following medical societies: American Academy of Dermatology, American Society of Dermatopathology, Texas Medical Association
Chief Editor
Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine
Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology
Susan M Swetter, MD Director, Pigmented Lesion and Melanoma Program, Professor, Department of Dermatology, Stanford University Medical Center and Cancer Institute, Veterans Affairs Palo Alto Health Care System
Susan M Swetter, MD is a member of the following medical societies: American Academy of Dermatology, Women's Dermatologic Society, American Society of Clinical Oncology, Society for Melanoma Research, Eastern Cooperative Oncology Group, American Medical Association, Pacific Dermatologic Association, Society for Investigative Dermatology
Acknowledgements
Misha A Rosenbach, MD Assistant Professor, Departments of Medicine and Dermatology, Hospital of the University of Pennsylvania
Misha A Rosenbach, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Academy, Medical Dermatology Society, and Women's Dermatologic Society
Disclosure: Centocor Grant/research funds None
Dina D Strachan, MD Assistant Clinical Professor, Department of Dermatology, St Vincent's Medical Center
References
- Berk MA, Lorincz AL. Scleredema adultorum of Buschke and primary hyperparathyroidism. Int J Dermatol. 1988 Nov. 27(9):647-9. [Medline].
- Miyagawa S, Dohi K, Tsuruta S, Shirai T. Scleredema of Buschke associated with rheumatoid arthritis and Sjögren's syndrome. Br J Dermatol. 1989 Oct. 121(4):517-20. [Medline].
- Yachoui R, Traisak P, Jagga S. Scleredema in a Patient with AIDS-Related Lipodystrophy Syndrome. Case Rep Endocrinol. 2013. 2013:943798. [Medline]. [Full Text].
- Matsunaga J, Hara M, Tagami H. Scleredema of Buschke associated with malignant insulinoma. Br J Dermatol. 1992 May. 126(5):527-8. [Medline].
- Manchanda Y, Das S, Sharma VK, Srivastava DN. Scleredema associated with carcinoma of the gall bladder. Br J Dermatol. 2005 Jun. 152(6):1373-4. [Medline].
- Yu JI, Park W, Lee KK, Park W. Scleredema adultorum of Buschke associated with a carcinoid tumor. Int J Dermatol. 2009 Jul. 48(7):784-6. [Medline].
- Cole GW, Headley J, Skowsky R. Scleredema diabeticorum: a common and distinct cutaneous manifestation of diabetes mellitus. Diabetes Care. 1983 Mar-Apr. 6(2):189-92. [Medline].
- Sattar MA, Diab S, Sugathan TN, Sivanandasingham P, Fenech FF. Scleroedema diabeticorum: a minor but often unrecognized complication of diabetes mellitus. Diabet Med. 1988 Jul-Aug. 5(5):465-8. [Medline].
- Rimon D, Lurie M, Storch S, et al. Cardiomyopathy and multiple myeloma. Complications of scleredema adultorum. Arch Intern Med. 1988 Mar. 148(3):551-3. [Medline].
- Isaac A, Costa I, Leal I. Scleredema of Buschke in a child with cardiac involvement. Pediatr Dermatol. 2010 May-Jun. 27(3):315-7. [Medline].
- Wright RA, Bernie H. Scleredema adultorum of Buschke with upper esophageal involvement. Am J Gastroenterol. 1982 Jan. 77(1):9-11. [Medline].
- Sansom JE, Sheehan AL, Kennedy CT, Delaney TJ. A fatal case of scleredema of Buschke. Br J Dermatol. 1994 May. 130(5):669-70. [Medline].
- Heilbron B, Saxe N. Scleredema in an infant. Arch Dermatol. 1986 Dec. 122(12):1417-9. [Medline].
- Nagi A, Memon IA. Scleredema of Buschke in pediatric age group. J Coll Physicians Surg Pak. 2005 May. 15(5):311-2. [Medline].
- Alp H, Orbak Z, Aktas A. Scleredema adultorum due to streptococcal infection. Pediatr Int. 2003 Feb. 45(1):101-3. [Medline].
- Tran K, Boyd KP, Robinson MR, Whitlow M. Scleredema diabeticorum. Dermatol Online J. 2013 Dec 16. 19(12):20718. [Medline].
- Farrell AM, Branfoot AC, Moss J, Papadaki L, Woodrow DF, Bunker CB. Scleredema diabeticorum of Buschke confined to the thighs. Br J Dermatol. 1996 Jun. 134(6):1113-5. [Medline].
- Ioannidou DI, Krasagakis K, Stefanidou MP, Karampekios S, Panayiotidis J, Tosca AD. Scleredema adultorum of Buschke presenting as periorbital edema: a diagnostic challenge. J Am Acad Dermatol. 2005 Feb. 52(2 Suppl 1):41-4. [Medline].
- Alp H, Orbak Z, Aktas A. Scleredema adultorum due to streptococcal infection. Pediatr Int. 2003 Feb. 45(1):101-3. [Medline].
- Cron RQ, Swetter SM. Scleredema revisited. A poststreptococcal complication. Clin Pediatr (Phila). 1994 Oct. 33(10):606-10. [Medline].
- Malhotra AK, Sethuraman G, Das AK, Sharma VK. Scleredema following scabies infestation. Pediatr Dermatol. 2008 Jan-Feb. 25(1):136-8. [Medline].
- Angeli-Besson C, Koeppel MC, Jacquet P, Andrac L, Sayag J. Electron-beam therapy in scleredema adultorum with associated monoclonal hypergammaglobulinaemia. Br J Dermatol. 1994 Mar. 130(3):394-7. [Medline].
- McFadden N, Ree K, Soyland E, Larsen TE. Scleredema adultorum associated with a monoclonal gammopathy and generalized hyperpigmentation. Arch Dermatol. 1987 May. 123(5):629-32. [Medline].
- Ikeda Y, Suehiro T, Abe T, et al. Severe diabetic scleredema with extension to the extremities and effective treatment using prostaglandin E1. Intern Med. 1998 Oct. 37(10):861-4. [Medline].
- Krasagakis K, Hettmannsperger U, Trautmann C, Tebbe B, Garbe C. Persistent scleredema of Buschke in a diabetic: improvement with high-dose penicillin. Br J Dermatol. 1996 Mar. 134(3):597-8. [Medline].
- Tsunemi Y, Ihn H, Fujita H, Asashima N, Saeki H, Tamaki K. Square-shaped scleredema in the back: probably induced by mechanical stress. Int J Dermatol. 2005 Sep. 44(9):769-70. [Medline].
- Ranganathan P. Infliximab-induced scleredema in a patient with rheumatoid arthritis. J Clin Rheumatol. 2005 Dec. 11(6):319-22. [Medline].
- Santos-Juanes J, Osuna CG, Iglesias JR, De Quiros JF, del RÃo JS. Treatment with chemotherapy of scleredema associated with Ig A myeloma. Int J Dermatol. 2001 Nov. 40(11):720-1. [Medline].
- Kurihara Y, Kokuba H, Furue M. Case of diabetic scleredema: diagnostic value of magnetic resonance imaging. J Dermatol. 2011 Jul. 38(7):693-6. [Medline].
- Sommer LL, Heymann WR. Fulminans in dermatology: a call to action: a recommendation for consideration of the term scleredema fulminans. J Clin Aesthet Dermatol. 2014 Jun. 7(6):42-5. [Medline]. [Full Text].
- Mattheou-Vakali G, Ioannides D, Thomas T, Lazaridou E, Tsogas P, Minas A. Cyclosporine in scleredema. J Am Acad Dermatol. 1996 Dec. 35(6):990-1. [Medline].
- Eberlein-Konig B, Vogel M, Katzer K, et al. Successful UVA1 phototherapy in a patient with scleredema adultorum. J Eur Acad Dermatol Venereol. 2005 Mar. 19(2):203-4. [Medline].
- Thumpimukvatana N, Wongpraparut C, Lim HW. Scleredema diabeticorum successfully treated with ultraviolet A1 phototherapy. J Dermatol. 2010 Dec. 37(12):1036-9. [Medline].
- Yoshimura J, Asano Y, Takahashi T, Uwajima Y, Kagami S, Honda H, et al. A case of scleredema adultorum successfully treated with narrow-band ultraviolet B phototherapy. Mod Rheumatol. 2014 Feb 5. [Medline].
- Kokpol C, Rajatanavin N, Rattanakemakorn P. Successful Treatment of Scleredema Diabeticorum by Combining Local PUVA and Colchicine: A Case Report. Case Rep Dermatol. 2012 Sep. 4(3):265-8. [Medline]. [Full Text].
- Grundmann-Kollmann M, Ochsendorf F, Zollner TM, Spieth K, Kaufmann R, Podda M. Cream PUVA therapy for scleredema adultorum. Br J Dermatol. 2000 May. 142(5):1058-9. [Medline].
- Hager CM, Sobhi HA, Hunzelmann N, et al. Bath-PUVA therapy in three patients with scleredema adultorum. J Am Acad Dermatol. 1998 Feb. 38(2 Pt 1):240-2. [Medline].
- Tamburin LM, Pena JR, Meredith R, Soong VY. Scleredema of Buschke successfully treated with electron beam therapy. Arch Dermatol. 1998 Apr. 134(4):419-22. [Medline].
- Alsaeedi SH, Lee P. Treatment of scleredema diabeticorum with tamoxifen. J Rheumatol. 2010 Dec. 37(12):2636-7. [Medline].
- Lee FY, Chiu HY, Chiu HC. Treatment of acquired reactive perforating collagenosis with allopurinol incidentally improves scleredema diabeticorum. J Am Acad Dermatol. 2011 Oct. 65(4):e115-7. [Medline].
- Yüksek J, Sezer E, Köseoglu D, Markoç F, Yildiz H. Scleredema treated with broad-band ultraviolet A phototherapy plus colchicine. Photodermatol Photoimmunol Photomed. 2010 Oct. 26(5):257-60. [Medline].
- Bray SM, Varghese S, English JC 3rd. Ultrasonic massage and physical therapy for scleredema: improving activities of daily living. Arch Dermatol. 2010 Apr. 146(4):453-4. [Medline].
- Rota E, Nallino MG, Bainotti S, Formica M. Nephrogenic systemic fibrosis: an unusual scleroderma-like fibrosing disorder. Rheumatol Int. 2009 Aug 20. [Medline].
- Stables GI, Taylor PC, Highet AS. Scleredema associated with paraproteinaemia treated by extracorporeal photopheresis. Br J Dermatol. 2000 Apr. 142(4):781-3. [Medline].
- Aichelburg MC, Loewe R, Schicher N, Sator PG, Karlhofer FM, Stingl G, et al. Successful treatment of poststreptococcal scleredema adultorum Buschke with intravenous immunoglobulins. Arch Dermatol. 2012 Oct. 148(10):1126-8. [Medline].
- Eastham AB, Femia AN, Velez NF, Smith HP, Vleugels RA. Paraproteinemia-associated scleredema treated successfully with intravenous immunoglobulin. JAMA Dermatol. 2014 Jul 1. 150(7):788-9. [Medline].
- Barde C, Masouyé I, Saurat JH, Le Gal FA. [Scleroedema adultorum Buschke in a diabetic subject: intravenous immunoglobulin therapy]. Ann Dermatol Venereol. 2009 Apr. 136(4):360-3. [Medline].
- Rani JD, Patil SG, Murthy ST, Koshy AV, Nagpal D, Gupta S. Juvenile scleredema of Buschke. J Contemp Dent Pract. 2012 Jan 1. 13(1):111-4. [Medline].
Middle-aged man who has diabetes with scleredema on the upper part of the back.
Middle-aged man who has diabetes with scleredema on the upper part of the back.